Synergistic fungicide composition

ABSTRACT

A synergistic fungicide composition, a formulation method and a use thereof are provided. The composition contains two active components A and B, where the active component A is benziothiazolinone, the active component B is one selected from dithianon, dimethomorph, iprodione and epoxiconazol, and the weight ratio of the two components is 1:50 to 50:1, and preferably 1:30 to 30:1. Test results show that, the fungicide composition has a significant synergistic effect, and more importantly, the application amount and the use-cost are reduced. The fungicide composition is effective in preventing and treating certain fungal diseases of crops such as food crops, vegetables and fruits.

This application is the U.S. national phase of International Application No. PCT/CN2012/080379 Filed on 20 Aug. 2012. which designated the U.S. and claims priority to Chinese Application No. 201210287687.2 filed on 13 Aug. 2012, the entire contents of each of which are hereby incorporated by reference.

BACKGROUND

1. Technical Field

The present invention belongs to the field of agricultural plant protection, particularly to a fungicide composition with improved performance, and specifically relates to a fungicide composition containing two active components.

2. Related Art

Benziothiazolinone is a fungicide and has the following functions and features: being a novel broad-spectrum fungicide, and being effective in preventing and treating fungal diseases. In the fungicidal process, the nucleus structure of the pathogenic fungi is destroyed, resulting lost of the heat part and death due to failure, the metabolism of the pathogenic fungus cells was interfered, resulting in physiologic disorders, and finally, leading to death. The pathogenic fungi are completely killed, and the desired effect of eradicating pathogenic fungi is achieved. Benziothiazolinone is mainly used in preventing and treating cucumber downy mildew, pear scab, apple scab, orange anthracnose, grape anthracnose, and is effective in preventing and treating various bacterial diseases and fungal diseases.

Dimethomorph is a morpholine-based broad-spectrum fungicide, has a unique mode of action on fungi of Peronosporales and Peronophthoraceae of phycomycetes, and is mainly to cause degradation of sporangium wall, so as to cause death of fungi. Dimethomorph is fungicide dedicated to oomycetes fungi, and has the functions and features of destroying the formation of cell membrane, having effects in all stages of life cycle of oomycetes, being particularly sensitive in the formation stages of sporangiophores and oospores, being inhibited at a very low concentration (0.25 μg/ml), and having no cross resistance with phenylamides reagents.

Dithianon is a protective fungicide used for various leaf diseases of many pomefruits and stone fruits, has multi-mechanism. By reacting with a sulfur-containing groups and interfering with cell respiration, dithianon inhibits a series of fungal enzymes, and finally causes death of fungi. Dithianon has good protective activity and a certain therapeutic activity. Suitable fruit crops include pomefruits and stone fruits such as apple, pear, peach, apricots, cherry, citrus, coffee, grape, strawberry and hop. Except powdery mildew, objects of prevention and treatment include almost all fruit tree diseases such as scab, mildew disease, leaf spot, rust, anthracnose, scab, downy mildew and brown rot.

Iprodione is a high-efficient dicarbonylimides broad-spectrum contact-type fungicide, has a certain treatment and prevention effect, and can be absorbed through roots and exert the systemic action. Iprodione is effective in preventing and treating fungi resistant to benzimidazoles absorption-type fungicides, and is suitable in preventing and treating diseases such as early leaf disease, gray mold and early blight of various fruit trees, vegetables, fruits and other crops.

Epoxiconazol is an absorption-type triazoles fungicide, has the mechanism of action of inhibiting synthesis of ergosterol pathogenic fungus and hindering the formation of the cell wall of pathogenic fungi. Epoxiconazol not only has good protecting, treating and eradicating activity, but also has absorption and good residual activity. Epoxiconazol can improve the chitinase activity of crops, thereby causing shrink of fungal haustoria, and inhibiting the invasion of pathogenic fungi, which is the unique characteristic of epoxiconazol among all triazoles products. Epoxiconazol has a good prevention and treatment effect on diseases such as leaf spot, powdery mildew and rust of crops such as bananas, garlic, celery, beans, melons, asparagus, peanuts and sugar beet and anthracnose, white rot of grapes.

Actual experiences of fungicide have shown that repeat application of one specific active compound to prevent and treat fungi will results in quick selectivity of fungal strains in many cases, in order to lower risk of selectivity of fungal strains, a mixture of compounds of different activities are commonly used to prevent and treat harmful fungi presently. Active compounds having different mechanisms of action are combined to delay the generation of resistance, and reduce the application amount and prevention and treatment costs.

SUMMARY

In view of the problems of fungicide resistance and residual in soil in practical applications, the technical problem to be solved by the present invention is: screening two fungicides of different fungicidal principles for combination, to improve the prevention and treatment effect of the fungicide, delay the emergence of resistance, reduce the application amount and prevention and treatment costs.

In order to solve the above technical problems, the present invention provides a fungicide composition. The composition contains two active components A and B, the active component A is benziothiazolinone, and the active component B is one selected from dithianon, dimethomorph, iprodione and epoxiconazol. The inventers find from experiments that the fungicide composition has a significant synergistic effect, and more importantly, the application amount and the use-cost are reduced. Compounds containing the component A and the component B have different structures, different mechanisms of action, the fungicidal spectrum can be expanded by combination of the two components, and the emergence and development speed of resistance of the pathogenic fungi is delayed, and moreover, the component A and the component B have no cross resistance.

Another objective of the present invention is to provide a method for preparing a fungicide composition containing two active components A and B and a use of the fungicide composition containing two active components A and B in the preventing and treating food crop diseases in the field of agriculture.

In the fungicide composition, the weight ratio of the component A and the component B is 1:50 to 50:1, and preferably 1:30 to 30:1.

The fungicide composition of the present invention is composed of 6 wt % to 92 wt % of active components and 94 wt % to 8 wt % of fungicide adjuvants.

The present invention provides a use of a fungicide composition containing a component A (benziothiazolinone) and a component B (one selected from dithianon, dimethomorph, iprodione and epoxiconazol) in preventing and treating plant diseases.

The composition further contains a support, an adjuvant and/or a surfactant. During application, a common adjuvant can be mixed with the composition.

Suitable adjuvants may be a solid or liquid, and are generally a substance commonly used in formulation processing process, for example, natural or regenerated minerals, solvents, dispersing agents, wetting agents, adhesives, thickeners, binders or fertilizers.

A method for applying the composition of the present invention includes: applying the composition of the present invention on the aboveground part of plants, especially the leaves or foliages. The frequency of application and application amount depend on the biological characteristics and the climate survival conditions of the pathogen. A liquid formulation containing the composition may be used to wet the plant growing place such as rice field, or the composition may be applied in the soil in the solid form, such as in the granular form (soil application), so that the composition can get into the plant body (systemic action) through the plant roots from the soil.

These compositions may merely contain the active components and be applied, and may also mixed with additives for use, so the composition of the present invention may be formulated into various formulations, for example, wettable powder, a suspension, an oil suspension, a water dispersible granule, an emulsion in water and a microemulsion. According to the properties of these compositions and the purpose to be achieved by applying the composition as well as the environmental conditions, the method for applying the composition may be selected to be spraying, atomizing, dusting, scattering or pouring and the like.

The composition of the present invention can be formulated into various formulations by known methods, the active components and an adjuvant such as a solvent and a solid support may be fully mixed with a surfactant and granulated when required, and formulated into a desired formulation.

The solvent may be selected from: aromatic hydrocarbons, and preferably aromatic hydrocarbons containing 8 to 12 carbon atoms, for example, xylene mixture or substituted benzene; phthalates, for example, dibutyl phthalates and dioctyl phthalate; aliphatic hydrocarbons, for example, cyclohexane and paraffins; alcohols and glycols and ethers and esters thereof, for example, ethanol, ethylene glycol, ethylene glycol monomethyl; ketones, for example, cyclohexanone; strongly polar solvent, for example, N-methyl-2-pyrrolidone, dimethyl sulfoxide and dimethylformamide; and vegetable oils, for example, soybean oil.

The solid supports useful in powder and dispersible granule are generally natural mineral fillers, for example, talc, kaolin, montmorillonite and attapulgite. For the control of the physical performance of the composition, highly dispersed silicic acid or a highly dispersed adsorbing polymer support such as a granular adsorbing support and non-adsorbing support may be added, where a suitable granular adsorbing support is porous, for example, pumice, bentonite and bentonite; a suitable non-adsorbing support is, for example, calcite and sand. Furthermore, a large amount of inorganic or organic preformed granular materials, especially, dolomite, may be used as support.

According to the chemical properties of the active components in the composition of the present invention, a suitable surfactant is lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or ammonium salts, alkylaryl sulfonates, alkyl sulfates, alkyl sulfonates, fatty alcohol sulphates and fatty acids and sulfated fatty alcohol ethylene glycol esters, condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensates of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, polyoxyethylene octyl phenyl ether, ethoxylated iso-octyl phenol, octyl phenol, nonylphenol, alkylaryl polyglycol ethers, triutylbenzene polyglycol ethers, tristearylphenyl polyglycol ethers, alkylaryl polyether alcohols, ethoxylated caster oil, polyoxyethylene alkyl ethers, ethylene oxide condensates, ethoxylated polyoxypropylene, lauric acid polyethylene glycol ether acetal, sorbate, lignosulphite wasterwater and methylcellulose.

The two active components in the composition of the present invention has a synergistic effect, and the activity of the composition is more significant than the sum of the expected activity of using single compounds and the individual activity of single compounds. Due to the synergistic effect, the application amount is decreased, and the fungicidal control spectrum is broadened, the prevention and treatment effects can be achieved quickly and last longer, so that by merely one or several times of application, the fungi harmful to plants can be controlled better, and the possible application interval is widened. There features are specially required in the practice process of controlling plant fungi. The composition of the present invention is especially effective for the following food crop diseases: cucumber downy mildew pathogenic fungi, cucumber gray mold, sigatoka, grape downy mildew and litchi blight.

The fungicide composition of the present invention also has other features: 1. the mixture of composition of the present invention has a significant synergistic effect; 2, since the two single components of the composition have great difference in structure, and completely different mechanisms of action, and have no cross resistance, the resistance generated when the two single components are used alone can be delayed; 3. the composition of the present invention is safe to crops and has a good prevention and treatment effect. It is proved by test that, the fungicide composition of the present invention has stable chemical properties and significant synergistic effect, and exhibits a significant synergistic effect and complementary effect on prevention and treatment targets.

BRIEF DESCRIPTION OF THE DRAWINGS

No drawings.

DETAILED DESCRIPTION

In order to make the objective, technical solutions and advantages of the present invention clearer and more comprehensive, the present invention is further described in detail below with the following embodiments. It should be understood that, the specific embodiment described herein are merely used to illustrate the present invention, but are not intended to limit the present invention, and any modification, equivalent replacement and improvement made within the spirit and principle of the present invention shall all fall within the protection scope of the present invention.

Percentages in all formulas in the following embodiments all are weight percentages. Processes for processing the preparations of the composition of the present invention all are existing technologies, and may vary according to different conditions.

I) Embodiments of Preparation of Formulations

(I) Processing of Water Dispersible Granule and Embodiments

The active component benziothiazolinone and one of dithianon, dimethomorph, iprodione and epoxiconazol were fully mixed with an adjuvant and a filler at the formula ratio, the mixture was pulverized into wettable powder by airflow, and the wettable powder was mixed with a certain amount of water and then subjected to extrusion granulation, drying and sieving, to obtain the water dispersible granule product.

Embodiment 1 62% Benziothiazolinone.Dithianon Water Dispersible Granule

60% benziothiazolinone, 2% dithianon, 4% sodium alkyl naphthalene sulfonate, 3% sodium dodecyl sulfonate, 3% ammonium sulfate, complemented to 100% with light calcium carbonate.

Embodiment 2 65% Benziothiazolinone.Dithianon Water Dispersible Granule

2% benziothiazolinone, 63% dithianon, 5% sodium lignosulfonate, 7% sodium methyl naphthalene sulfonate-formaldehyde condensate, 3% sodium dodecyl sulfate, complemented to 100% with diatomite.

Embodiment 3 65% Benziothiazolinone.Dimethomorph Water Dispersible Granule

63% benziothiazolinone, 2% dimethomorph, 6% sodium lignosulfonate, 3% sodium dodecyl sulfonate, 1% xanthan gum, 1% sodium carboxymethyl starch, complemented to 100% with attapulgite.

Embodiment 4 85% Benziothiazolinone.Dimethomorph Water Dispersible Granule

2% benziothiazolinone, 83% dimethomorph, 1% ammonium sulfate, 2% alginate, 1% sodium methyl naphthalene sulfonate-formaldehyde condensate, 1% organosilicone, complemented to 100% with bentonite.

Embodiment 5 62% Benziothiazolinone.Iprodione Water Dispersible Granule

60% benziothiazolinone, 2% iprodione, 2% sodium dodecyl sulfonate, 2% sodium alkyl naphthalene sulfonate, 3% ammonium sulfate, complemented to 100% with light calcium carbonate.

Embodiment 6 75% Benziothiazolinone.Iprodione Water Dispersible Granule

2% benziothiazolinone, 73% iprodione, 5% sodium methyl naphthalene sulfonate-formaldehyde condensate, 4% sodium lignosulfonate, 3% sodium dodecyl sulfate, complemented to 100% with diatomite.

Embodiment 7 62% Benziothiazolinone.Epoxiconazol Water Dispersible Granule

60% benziothiazolinone, 2% epoxiconazol, 1% sodium carboxymethyl starch, 4% sodium dodecyl sulfonate, 4% sodium lignosulfonate, 1% xanthan gum, complemented to 100% with attapulgite.

Embodiment 8 62% Benziothiazolinone.Epoxiconazol Water Dispersible Granule

2% benziothiazolinone, 60% epoxiconazol, 1% ammonium sulfate, 2% alginate, 1% sodium methyl naphthalene sulfonate-formaldehyde condensate, 1% organosilicone, complemented to 100% with bentonite.

(II) Processing of Suspension and Embodiments

The active component benziothiazolinone and one of dithianon, dimethomorph, iprodione and epoxiconazol were fully mixed with the components such as a dispersant, a wetting agent, a thickener and water at the formula ratio, the mixture was then subjected to sanding and/or high-speed shearing, to obtain a semi-finished product, and the semi-finished product was fully mixed water after analysis and filtered, to obtain the finished product.

Embodiment 9 35% Benziothiazolinone.Dithianon Suspension

25% benziothiazolinone, 100% dithianon, 7% sodium lignosulfonate, 0.8% xanthan gum, 3% bentonite, 1% magnesium aluminum silicate, 4% ethylene glycol, complemented to 100% with water.

Embodiment 10 36% Benziothiazolinone.Dithianon Suspension

12% benziothiazolinone, 24% dithianon, 6% sodium methyl naphthalene sulfonate-formaldehyde condensate, 4% bentonite, 5% glycerol, complemented to 100% with water.

Embodiment 11 42% Benziothiazolinone.Dimethomorph Suspension

40% benziothiazolinone, 2% dimethomorph, 7% polyoxyethylene fatty alcohol ether phosphate, 3% white carbon black, 6% glycerol, 2% calcium benzoate, complemented to 100% with water.

Embodiment 12 32% Benziothiazolinone.Dimethomorph Suspension

5% benziothiazolinone, 27% dimethomorph, 7% sodium lignosulfonate, 3% white carbon black, 6% ethylene glycol, 1% xanthan gum, complemented to 100% with water.

Embodiment 13 55% Benziothiazolinone.Iprodione Suspension

50% benziothiazolinone, 5% iprodione, 7% polyoxyethylene fatty alcohol ether phosphate, 3% white carbon black, 6% glycerol, 2% calcium benzoate, complemented to 100% with water.

Embodiment 14 42% Benziothiazolinone.Iprodione Suspension

2% benziothiazolinone, 40% iprodione, 7% sodium lignosulfonate, 3% white carbon black, 6% ethylene glycol, 1% xanthan gum, complemented to 100% with water.

Embodiment 15 55% Benziothiazolinone.Epoxiconazol Suspension

50% benziothiazolinone, 5% epoxiconazol, 7% polyoxyethylene fatty alcohol ether phosphate, 3% white carbon black, 6% glycerol, 2% calcium benzoate, complemented to 100% with water.

Embodiment 16 55% Benziothiazolinone.Epoxiconazol Suspension

5% benziothiazolinone, 50% epoxiconazol, 7% sodium lignosulfonate, 3% white carbon black, 6% ethylene glycol, 1% xanthan gum, complemented to 100% with water.

(III) Processing of Wettable Powder and Embodiments

The active component A benziothiazolinone and the active component B of one of dithianon, dimethomorph, iprodione and epoxiconazol were fully mixed with various adjuvants and fillers at ratios, and the mixture was pulverized by an ultrafine pulverizer, to obtain a wettable powder.

Embodiment 17 90% Benziothiazolinone.Dithianon Wettable Powder

2% benziothiazolinone, 88% dithianon, 2% calcium lignosulphonate, 1% sodium dodecylbenzene sulfonate, 2% bentonite, complemented to 100% with attapulgite.

Embodiment 18 88% Benziothiazolinone.Dithianon Wettable Powder

86% benziothiazolinone, 2% dithianon, 1% polyoxyethylene alkyl ether sulfonate, 2% nekal, 1.5% bentonite, 2% white carbon black, complemented to 100% with diatomite 100%.

Embodiment 19 55% Benziothiazolinone.Dithianon Wettable Powder

25% benziothiazolinone, dithianon 30%, 6% alkyl sulfonate, 6% sodium lignosulfonate, 11% white carbon black, complemented to 100% with kaolin.

Embodiment 20 88% Benziothiazolinone.Dimethomorph Wettable Powder

86% benziothiazolinone, 2% dimethomorph, 2% polyoxyethylene octyl phenyl ether, 6% sodium lignosulfonate, 4% white carbon black, complemented to 100% with diatomite.

Embodiment 21 50% Benziothiazolinone.Dimethomorph Wettable Powder

25% benziothiazolinone, 25% dimethomorph, 7% calcium lignosulphonate, 5% white carbon black, 3% sodium dodecylbenzene sulfonate, complemented to 100% with attapulgite.

Embodiment 22 62% Benziothiazolinone.Dimethomorph Wettable Powder

2% benziothiazolinone, 60% dimethomorph, 5% calcium lignosulphonate, 4% bentonite, 3% polyoxyethylene octyl phenyl ether, complemented to 100% with attapulgite.

Embodiment 23 85% Benziothiazolinone.Iprodione Wettable Powder

83% benziothiazolinone, 2% iprodione, 1% polyoxyethylene octyl phenyl ether, 2% sodium lignosulfonate, 3% white carbon black, complemented to 100% with diatomite.

Embodiment 24 50% Benziothiazolinone.Iprodione Wettable Powder

25% benziothiazolinone, 25% iprodione, 3% sodium dodecylbenzene sulfonate, 5% white carbon black, 7% calcium lignosulphonate, complemented to 100% with attapulgite.

Embodiment 25 85% Benziothiazolinone.Iprodione Wettable Powder

3% benziothiazolinone, 82% iprodione, 5% calcium lignosulphonate, 4% bentonite, 3% polyoxyethylene octyl phenyl ether, complemented to 100% with attapulgite.

Embodiment 26 88% Benziothiazolinone.Epoxiconazol Wettable Powder

2% benziothiazolinone, 86% epoxiconazol, 2% sodium dodecylbenzene sulfonate, 1% bentonite, 2% calcium lignosulphonate, complemented to 100% with attapulgite.

Embodiment 27 86% Benziothiazolinone.Epoxiconazol Wettable Powder

84% benziothiazolinone, 2% epoxiconazol, 1% nekal, 2% polyoxyethylene alkyl ether sulfonate, 15% bentonite, 2% white carbon black, complemented to 100% with diatomite 100%.

Embodiment 28 50% Benziothiazolinone.Epoxiconazol Wettable Powder

25% benziothiazolinone, 25% epoxiconazol, 6% sodium lignosulfonate, 6% alkyl sulfonate, 11% white carbon black, complemented to 100% with kaolin.

(IV) Processing of Microemulsion and Embodiments

The active component A benziothiazolinone and the active component B of one of dithianon, dimethomorph, iprodione and epoxiconazol were completely dissolved in a solvent, and at the same time, an emulsifier, a synergistic effect adjuvant and a cryoprotectant were added with stirring, after the system was fully mixed, water was slowly added to the mixture, and the mixture was fully stirred, to obtain a microemulsion of different contents.

Embodiment 29 18% Benziothiazolinone.Dithianon Microemulsion

3% benziothiazolinone, 15% dithianon, 15% acetone, 0.5% compound sodium nitrophenolate, 5% alkyl polyoxyethylene ether and nonylphenol polyoxyethylene ether, 1% propylene glycol, 2% urea, complemented to 100% with water.

Embodiment 30 30% Benziothiazolinone.Dithianon Microemulsion

25% benziothiazolinone, 5% dithianon, 4% polyoxyethylene aliphatate and phenethyl phenol polyoxyethylene ether, 2% glycerol, 11% methanol, 1% azone, complemented to 100% with water.

Embodiment 31 15% Benziothiazolinone.Dimethomorph Microemulsion

5% benziothiazolinone, 10% dimethomorph, 16% alkyl benzene sulfonate and alkyl naphthalene sulfonate, 1% thiazone, 16% ethyl acetate, 1% propylene glycol, complemented to 100% with water.

Embodiment 32 15% Benziothiazolinone.Dimethomorph Microemulsion

10% benziothiazolinone, 5% dimethomorph, 8% calcium dodecylbenzene sulfonate, 0.5% thiazone, 14% sorbic acid, 3% polyethylene glycol, complemented to 100% with water.

Embodiment 33 18% Benziothiazolinone.Iprodione Microemulsion

6% benziothiazolinone, 12% iprodione, 15% acetone, 0.5% compound sodium nitrophenolate, 5% alkyl polyoxyethylene ether and nonylphenol polyoxyethylene ether, 1% propylene glycol, 2% urea, complemented to 100% with water.

Embodiment 34 21% Benziothiazolinone.Iprodione Microemulsion

20% benziothiazolinone, 1% iprodione, 4% polyoxyethylene aliphatate and phenethyl phenol polyoxyethylene ether, 2% glycerol, 11% methanol, 1% azone, complemented to 100% with water.

Embodiment 35 12% Benziothiazolinone.Epoxiconazol Microemulsion

2% benziothiazolinone, 10% epoxiconazol, 1% propylene glycol, 13% alkyl benzene sulfonate and alkyl naphthalene sulfonate, 1% thiazone, 11% ethyl acetate, complemented to 100% with water.

Embodiment 36 15% Benziothiazolinone.Epoxiconazol Microemulsion

10% benziothiazolinone, 5% epoxiconazol, 14% sorbic acid, 1% thiazone, 7% calcium dodecylbenzene sulfonate, 2% polyethylene glycol, complemented to 100% with water.

(V) Processing of Emulsion in Water and Embodiments

In an emulsifying kettle, the active component A benziothiazolinone and the active component B of one of dithianon, dimethomorph, iprodione and epoxiconazol were fully mixed with a solvent and an adjuvant under mechanical stirring, an emulsifier and a stabilizer were then added and fully stirred, finally, water was added, and the mixture was stirred for 10 to 30 min at a rotation rate of 100 to 12000 rpm, to obtain a uniform emulsion product.

Embodiment 37 42% Benziothiazolinone.Dithianon Emulsion in Water

40% benziothiazolinone, 2% dithianon, 4% dimethyl N-phthalate, 3% nonylphenol phenoxy vinyl ether, 2% 2,6-tert-butyl-4-methylphenol, 3% ethylene glycol, 1% polyvinyl alcohol, 1% calcium benzoate, 0.8% organic silicon defoamer, complemented to 100% with water.

Embodiment 38 44% Benziothiazolinone.Dithianon Emulsion in Water

4% benziothiazolinone, 40% dithianon, 4% butylhydroxyanisole, 3% plyisobutylene anhydride-polyethylene glycol copolymer, 2% propylene glycol, 3% xanthan gum, 1% polyvinyl alcohol, 1.2% organic silicon defoamer, complemented to 100% with water.

Embodiment 39 22% Benziothiazolinone.Dimethomorph Emulsion in Water

20% benziothiazolinone, 2% dimethomorph, 3% polyoxyethylene block copolymer, 1% propylene glycol, 2% xanthan gum, 3% plyisobutylene anhydride-polyethylene glycol copolymer, 1.2% organic silicon defoamer, complemented to 100% with water.

Embodiment 40 22% Benziothiazolinone.Dimethomorph Emulsion in Water

2% benziothiazolinone, 20% dimethomorph, 2% N-dodecylpyrrolidone, 1% polyoxyethylene castor oil, 3% glycerol, 12% polyvinyl alcohol, 1% calcium benzoate, 2% isooctanol, complemented to 100% with water.

Embodiment 41 30% Benziothiazolinone.Iprodione Emulsion in Water

25% benziothiazolinone, 5% iprodione, 1% 2,6-tert-butyl-4-methylphenol, 2% nonylphenol phenoxy vinyl ether, 3% ethylene glycol, 1% calcium benzoate, 2% dimethyl N-phthalate, 1% polyvinyl alcohol, 1% organic silicon defoamer, complemented to 100% with water.

Embodiment 42 42% Benziothiazolinone.Iprodione Emulsion in Water

2% benziothiazolinone, 40% iprodione, 2% propylene glycol, 3% butylhydroxyanisole, 3% plyisobutylene anhydride-polyethylene glycol copolymer, 3% xanthan gum, 1% polyvinyl alcohol, 1.2% organic silicon defoamer, complemented to 100% with water.

Embodiment 43 21% Benziothiazolinone.Epoxiconazol Emulsion in Water

20% benziothiazolinone, 1% epoxiconazol, 1% propylene glycol, 1% xanthan gum, 2% plyisobutylene anhydride-polyethylene glycol copolymer, 2% polyoxyethylene block copolymer, 1.5% organic silicon defoamer, complemented to 100% with water.

Embodiment 44 42% Benziothiazolinone.Epoxiconazol Emulsion in Water

2% benziothiazolinone, 40% epoxiconazol, 2% polyoxyethylene castor oil, 1% N-dodecylpyrrolidone, 2% glycerol, 1.1% polyvinyl alcohol, 2% calcium benzoate, 1% isooctanol, complemented to 100% with water.

(VI) Processing of Oil Suspension and Embodiments

The active component A benziothiazolinone and the active component B of one of dithianon, dimethomorph, iprodione and epoxiconazol were mixed with various components such as a dispersant, a stabilizer, a defoamer and a solvent at the formula ratio, and the mixture was placed in a sanding kettle for milling, then sent to a homogenizer and fully mixed, to obtain the finished product.

Embodiment 45 42% Benziothiazolinone.Dithianon Oil Suspension

2% benziothiazolinone, 40% dithianon, 8% sodium lignosulfonate, 4% bentonite, 1% xanthan gum, 2% organic silicon defoamer, complemented to 100% with soybean oil.

Embodiment 46 55% Benziothiazolinone.Dithianon Oil Suspension

50% benziothiazolinone, 5% dithianon, 8% nekal, 5% bentonite, 2% organosilicone, complemented to 100% with engine oil.

Embodiment 47 30% Benziothiazolinone.Dimethomorph Oil Suspension

25% benziothiazolinone, 5% dimethomorph, 8% naphthalene sulfonic acid-formaldehyde condensate, 5% diatomite, 2% aluminium-magnesium silicate, complemented to 100% with dichloroethane.

Embodiment 48 42% Benziothiazolinone.Dimethomorph Oil Suspension

2% benziothiazolinone, 40% dimethomorph, 11% sodium lignosulfonate, 4% aerosil, 2% aluminium-magnesium silicate, complemented to 100% with castor oil.

Embodiment 49 18% Benziothiazolinone.Iprodione Oil Suspension

3% benziothiazolinone, 15% iprodione, 1% organic silicon defoamer, 3% bentonite, 7% sodium lignosulfonate, 1% xanthan gum, complemented to 100% with soybean oil.

Embodiment 50 22% Benziothiazolinone.Iprodione Oil Suspension

20% benziothiazolinone, 2% iprodione, 3% bentonite, 7% nekal, 2% organosilicone, complemented to 100% with engine oil.

Embodiment 51 30% Benziothiazolinone.Epoxiconazol Oil Suspension

25% benziothiazolinone, 5% epoxiconazol, 8% naphthalene sulfonic acid-formaldehyde condensate, 5% diatomite, 2% aluminium-magnesium silicate, complemented to 100% with dichloroethane.

Embodiment 52 45% Benziothiazolinone.Epoxiconazol Oil Suspension

15% benziothiazolinone, 30% epoxiconazol, 11% sodium lignosulfonate, 4% aerosil, 2% aluminium-magnesium silicate, complemented to 100% with castor oil.

II) Efficacy Verification Test

(I) Biological Assay Embodiments

1. Test of Toxicity of Compound Benziothiazolinone and Dithianon on Cucumber Downy Mildew Pathogenic Fungi

Subjects for Test: Cucumber Downy Mildew Pathogenic Fungi

The incidence of whole cucumber leaves was investigated according to test grading level, and the disease index and the prevention and treatment effect were calculated.

The prevention and treatment effect was converted into probability values (y), the heights of the chemicals (μg/ml) were converted into logarithm values (x), the toxicity equation and the median inhibition concentration EC50 were calculated by the least square method, and the toxicity index level co-toxicity coefficient (CTC) of the chemicals was calculated according to the Sun Yunpei's method. Actual toxicity index(ATI)=(EC50 of the standard reagent/EC50 of the test reagent)×100 Theoretical toxicity index(TTI)=the toxicity index of chemicalA×the percentage of A in the mixture+the toxicity index of chemical B×the percentage of B in the mixture Co-toxicity coefficient(CTC)=[Actual toxicity index(ATI) of the mixture/Theoretical toxicity index(TTI) of the mixture]×00

CTC≦80, indicating that the composition had the antagonistic effect, 80<CTC<120, indicating that the composition had the additive effect, and CTC≧20, indicating that the composition had the synergistic effect.

TABLE 1 Analysis of results of test of toxicity of benziothiazolinone, dithianon and compound benziothiazolinone and dithianon on cucumber downy mildew Co-toxicity EC₅₀ coefficient Names of reagents (μg/ml) ATI TTI (CTC) Benziothiazolinone 3.25 100.0 / / Dithianon 5.41 60.1 / / Benziothiazolinone:dithianon 2.37 137.13 99.215 138.215 ratio = 50:1 Benziothiazolinone:dithianon 1.91 170.16 98.67 172.454 ratio = 30:1 Benziothiazolinone:dithianon 1.58 205.69 96.37 213.438 ratio = 10:1 Benziothiazolinone:dithianon 2.08 156.25 80.05 195.191 ratio = 1:1 Benziothiazolinone:dithianon 2.26 143.81 63.73 225.655 ratio = 1:10 Benziothiazolinone:dithianon 3.79 85.61 61.43 139.358 ratio = 1:30 Benziothiazolinone:dithianon 4.18 77.76 60.88 127.720 ratio = 1:50

The results (Table 1) show that, the compound benziothiazolinone and dithianon has significantly improved prevention and treatment effect on cucumber downy mildew, indicating that the compound of the two has a significant synergistic effect on cucumber downy mildew pathogenic fungi. Especially when the ratio of benziothiazolinone and dithianon is in the range of 1:30 to 30:1, the co-toxicity coefficient of benziothiazolinone and dithianon is 135 and more, and the synergistic effect is significant.

2. Test of Toxicity of Compound Benziothiazolinone and Dimethomorph on Cucumber Downy Mildew

TABLE 2 Analysis of results of test of toxicity of benziothiazolinone, dimethomorph and compound benziothiazolinone and dimethomorph on cucumber downy mildew Co- toxicity EC₅₀ coefficient Names of reagents (μg/ml) ATI TTI (CTC) Benziothiazolinone 4.08 100.0 / / Dimethomorph 6.36 63.9 / / Benziothiazolinone:dimethomorph 2.99 136.5 99.29 137.48 ratio = 50:1 Benziothiazolinone:dimethomorph 2.40 170.0 98.835 172.00 ratio = 30:1 Benziothiazolinone:dimethomorph 2.12 192.4 96.718 198.93 ratio = 10:1 Benziothiazolinone:dimethomorph 2.01 203.0 81.95 247.71 ratio = 1:1 Benziothiazolinone:dimethomorph 2.91 140.2 67.18 208.69 ratio = 1:10 Benziothiazolinone:dimethomorph 3.33 122.5 65.17 187.97 ratio = 1:30 Benziothiazolinone:dimethomorph 4.87 83.8 64.6 129.72 ratio = 1:50

The results (Table 2) show that, the compound benziothiazolinone and dimethomorph has significantly improved prevention and treatment effect on cucumber downy mildew, indicating that the compound of the two has a significant synergistic effect on cucumber downy mildew pathogenic fungi. Especially when the ratio of benziothiazolinone and dimethomorph is in the range of 1:30 to 30:1, the co-toxicity coefficient of benziothiazolinone and dithianon is 170 and more, and the synergistic effect is significant.

3. Test of Toxicity of Compound Benziothiazolinone and Iprodione on Cucumber Downy Mildew

TABLE 3 Analysis of results of test of toxicity of benziothiazolinone, iprodione and compound benziothiazolinone and iprodione on cucumber downy mildew Co-toxicity EC₅₀ coefficient Names of reagents (μg/ml) ATI TTI (CTC) Benziothiazolinone 4.21 100.00 / / Iprodione 5.82 72.34 / / Benziothiazolinone:dimetho- 3.32 126.81 99.458 127.50 morph ratio = 50:1 Benziothiazolinone:iprodione 3.05 138.03 99.108 139.27 ratio = 30:1 Benziothiazolinone:iprodione 2.29 183.84 97.485 188.58 ratio = 10:1 Benziothiazolinone:iprodione 2.07 203.38 86.170 236.02 ratio = 1:1 Benziothiazolinone:iprodione 2.54 165.75 74.855 221.43 ratio = 1:10 Benziothiazolinone:iprodione 4.18 100.72 73.232 137.54 ratio = 1:30 Benziothiazolinone:iprodione 4.62 91.13 72.882 125.04 ratio = 1:50

The results (Table 3) show that, the compound benziothiazolinone and iprodione has significantly improved prevention and treatment effect on cucumber downy mildew, indicating that the compound of the two has a significant synergistic effect on cucumber downy mildew pathogenic fungi. Especially when the ratio of benziothiazolinone and iprodione is in the range of 1:30 to 30:1, the co-toxicity coefficient of benziothiazolinone and iprodione is 135 and more, and the synergistic effect is significant.

4. Test of Toxicity of Compound Benziothiazolinone and Epoxiconazol on Cucumber Downy Mildew

TABLE 4 Analysis of results of test of toxicity of benziothiazolinone, epoxiconazol and compound benziothiazolinone and epoxiconazol on cucumber downy mildew Co- EC₅₀ toxicity (μg/ coefficient Names of reagents ml) ATI TTI (CTC) Benziothiazolinone 3.81 100.00 / / Epoxiconazol 4.25 89.65 / / Benziothiazolinone:Epoxiconazol 2.90 131.343 99.797 131.61 ratio = 50:1 Benziothiazolinone:epoxiconazol 2.56 148.722 99.666 149.22 ratio = 30:1 Benziothiazolinone:epoxiconazol 1.97 193.680 99.059 195.52 ratio = 10:1 Benziothiazolinone:epoxiconazol 1.59 240.106 94.825 253.21 ratio = 1:1 Benziothiazolinone:epoxiconazol 1.94 196.383 90.591 216.78 ratio = 1:10 Benziothiazolinone:epoxiconazol 3.02 126.274 89.645 140.86 ratio = 1:30 Benziothiazolinone:epoxiconazol 3.51 108.403 89.353 121.32 ratio = 1:50

The results (Table 4) show that, the compound benziothiazolinone and epoxiconazol has significantly improved prevention and treatment effect on cucumber downy mildew, indicating that the compound of the two has a significant synergistic effect on cucumber downy mildew pathogenic fungi. Especially when the ratio of benziothiazolinone and epoxiconazol is in the range of 1:30 to 30:1, the co-toxicity coefficient of benziothiazolinone and epoxiconazol is 140 and more, and the synergistic effect is significant.

(II) Field Efficacy Verification Test

Test method: In the early period, the reagent was immediately sprayed for the first time, and 7 days later, the reagent was applied for the second time, each treatment had 4 sections, and each section had a size of 20 m². The incidence was investigated before application of the reagent and 10 days after the second application of the reagent, each section was randomly sampled at 5 points, 5 crops were investigated at each point, the percentage of the lesion area in the leaf area of each leave on the whole crop was investigated, the leaves were graded, and the disease index and the prevention and treatment effect were calculated.

${{Disease}\mspace{14mu}{index}} = {\frac{\Sigma\left( {{Incidence}\mspace{14mu}{of}\mspace{14mu}{leaves}\mspace{14mu}{of}\mspace{14mu}{various}\mspace{14mu}{levels} \times {Representative}\mspace{14mu}{value}\mspace{14mu}{of}\mspace{14mu}{this}\mspace{14mu}{level}} \right)}{\begin{matrix} {{The}\mspace{14mu}{total}\mspace{14mu}{number}\mspace{14mu}{of}\mspace{14mu}{leaves} \times} \\ {{Representative}\mspace{14mu}{value}\mspace{14mu}{of}\mspace{14mu}{the}\mspace{14mu}{highest}\mspace{14mu}{level}} \end{matrix}} \times 100}$ ${{Prevention}\mspace{14mu}{and}\mspace{14mu}{treatment}\mspace{14mu}{effect}\mspace{14mu}(\%)} = {\left( {1 - \frac{{Pre}\text{-}{reagent}\mspace{14mu}{control}\mspace{14mu}{disease}\mspace{14mu}{index} \times {Post}\text{-}{reagent}\mspace{14mu}{treatment}\mspace{14mu}{disease}\mspace{14mu}{index}}{{Post}\text{-}{reagent}\mspace{14mu}{control}\mspace{14mu}{disease}\mspace{14mu}{index}\mspace{14mu}{Pre}\text{-}{reagent}\mspace{14mu}{treatment}\mspace{14mu}{disease}\mspace{14mu}{index}}} \right) \times 100}$ Expected control efficiency(%)=X+Y−XY/100(where X and Yare control efficiency of single reagent)

Grading Standard:

0 grade: Having no lesion;

1 grade: having less than 5 leaf lesions, and the length of lesions being less than 1 cm;

3 grade: having 6 to 10 leaf lesions, and the length of some lesions being greater than 1 cm;

5 grade: having 11 to 25 leaf lesions, some lesions being contiguous, and the area of the lesions being 10% to 25% of the leaf area;

7 grade: having 26 and more leaf lesions, lesions being contiguous, and the area of the lesions being 26% to 50% of the leaf area;

9 grade: lesions being contiguous, and the area of the lesions being 50% and more of the leaf area or the entire leave withering up.

(1) Field Efficacy Verification Test of Compound Benziothiazolinone and Dithianon on Grape Downy Mildew

TABLE 5 Prevention and treatment effect of compound benziothiazolinone and dithianon mixture on grape downy mildew 11 days after second application of Disease index chemicals Application before Control Serial amount application of Disease efficiency number Chemicals for treatment (a.i.g/ha) reagents index (%) Embodiment 1 15% benziothiazolinone emulsion in water 125.8 2.79 6.46 85.8 50% dithianon suspension 4.2 3.21 50.51 3.5 Expected control efficiency after mixing the — — — 86.3 two components 62% benziothiazolinone•dithianon water 130.0 3.02 3.05 93.8 dispersible granule (benziothiazolinone:dithianon = 60:2) Embodiment 2 15% benziothiazolinone emulsion in water 4 2.81 40.00 12.7 50% dithianon suspension 126 2.9 11.25 76.2 Expected control efficiency after mixing the — — — 79.2 two components 65% benziothiazolinone•dithianon water 130.0 2.88 4.60 90.2 dispersible granule (benziothiazolinone:dithianon = 2:63) Embodiment 9 15% benziothiazolinone emulsion in water 92.8 2.69 10.75 75.5 50% dithianon suspension 37.2 2.79 39.26 13.7 Expected control efficiency after mixing the — — — 78.9 two components 35% benziothiazolinone•dithianon 130.0 2.72 2.35 94.7 suspension (benziothiazolinone:dithianon = 25:10) Embodiment 15% benziothiazolinone emulsion in water 43.4 2.85 23.56 49.3 10 50% dithianon suspension 86.6 2.98 30.37 37.5 Expected control efficiency after mixing the — — — 68.3 two components 36% benziothiazolinone•dithianon 130.0 2.83 2.17 95.3 suspension (benziothiazolinone:dithianon = 12:24) Embodiment 15% benziothiazolinone emulsion in water 2.9 2.76 40.87 9.2 17 50% dithianon suspension 127.1 3.04 11.15 77.5 Expected control efficiency after mixing the — — — 79.6 two components 90% benziothiazolinone•dithianon wettable 130.0 2.93 5.83 87.8 powder (benziothiazolinone:dithianon = 2:88) Embodiment 15% benziothiazolinone emulsion in water 127 3 6.75 86.2 18 50% dithianon suspension 3 2.87 45.35 3.1 Expected control efficiency after mixing the — — — 86.6 two components 88% benziothiazolinone•dithianon wettable 130.0 2.91 4.65 90.2 powder (benziothiazolinone:dithianon = 86:2) Embodiment 15% benziothiazolinone emulsion in water 59 2.79 20.15 55.7 19 50% dithianon suspension 71 2.85 31.46 32.3 Expected control efficiency after mixing the — — — 70.0 two components 55% benziothiazolinone•dithianon wettable 130.0 3.02 4.19 91.5 powder (benziothiazolinone:dithianon = 25:30) Embodiment 15% benziothiazolinone emulsion in water 21.6 2.68 28.63 34.5 29 50% dithianon suspension 108.4 2.89 22.01 53.3 Expected control efficiency after mixing the — — — 69.4 two components 18% benziothiazolinone•dithianon 130.0 2.75 3.36 92.5 microemulsion (benziothiazolinone:dithianon = 3:15) Embodiment 15% benziothiazolinone emulsion in water 108.4 2.87 10.06 78.5 30 50% dithianon suspension 21.6 2.93 43.62 8.7 Expected control efficiency after mixing the — — — 80.37 two components 30% benziothiazolinone•dithianon 130.0 2.85 3.63 92.2 microemulsion (benziothiazolinone:dithianon = 25:5) Embodiment 15% benziothiazolinone emulsion in water 123.8 2.68 6.86 84.3 37 50% dithianon suspension 6.2 2.89 45.15 4.2 Expected control efficiency after mixing the — — — 84.96 two components 42% benziothiazolinone•dithianon 130.0 2.75 3.86 91.4 microemulsion (benziothiazolinone:dithianon = 40:2) Embodiment 15% benziothiazolinone emulsion in water 11.8 2.76 34.34 23.7 38 50% dithianon suspension 118.2 2.85 16.03 65.5 Expected control efficiency after mixing the — — — 73.7 two components 44% benziothiazolinone•dithianon 130.0 3.11 3.14 93.8 microemulsion (benziothiazolinone:dithianon == 4:40) Embodiment 15% benziothiazolinone emulsion in water 6.2 2.9 39.11 17.3 45 50% dithianon suspension 123.8 2.85 14.36 69.1 Expected control efficiency after mixing the — — — 74.4 two components 42% benziothiazolinone•dithianon 130 2.79 4.32 90.5 microemulsion (benziothiazolinone:dithianon = 2:40) Embodiment 15% benziothiazolinone emulsion in water 118.2 3.05 9.05 81.8 46 50% dithianon suspension 11.8 3.25 49.23 7.1 Expected control efficiency after mixing the — — — 83.1 two components 55% benziothiazolinone•dithianon 130 2.99 3.17 93.5 microemulsion (benziothiazolinone:dithianon = 50:5) Water — — 2.93 46.93 — control (CK)

Test results (Table 5) show that, the compound benziothiazolinone and dithianon has significantly improved control efficiency on grape downy mildew, indicating that the compound of the two has a significant synergistic effect on grape downy mildew.

(2) Field Efficacy Verification Test of Compound Benziothiazolinone and Dimethomorph on Litchi Blight

TABLE 6 Prevention and treatment effect of compound benziothiazolinone and dimethomorph on litchi blight Disease 11 days after second index application before of chemicals Application application Control Serial amount of Disease efficiency number Chemicals for treatment (a.i.g/ha) reagents index (%) Embodiment 3 15% benziothiazolinone emulsion in water 145.4 2.51 5.95 81.2 50% dimethomorph wettable powder 19.6 2.63 30.89 6.8 Expected control efficiency after mixing the — — — 82.5 two components 65% benziothiazolinone•dimethomorph 150.0 2.52 3.52 88.9 water dispersible granule (benziothiazolinone:dimethomorph = 63:2) Embodiment 4 15% benziothiazolinone emulsion in water 3.5 2.32 28.50 2.5 50% dimethomorph wettable powder 146.5 2.29 6.95 75.9 Expected control efficiency after mixing the — — — 76.5 two components 85% benziothiazolinone•dimethomorph 150 2.52 4.51 85.8 water dispersible granule (benziothiazolinone:dimethomorph = 2:83) Embodiment 15% benziothiazolinone emulsion in water 142.9 2.45 6.14 80.1 11 50% dimethomorph wettable powder 7.1 2.38 28.40 5.3 Expected control efficiency after mixing the — — — 81.2 two components 42% benziothiazolinone•dimethomorph 150.0 2.53 4.50 85.9 suspension (benziothiazolinone:dimethomorph = 40:2) Embodiment 15% benziothiazolinone emulsion in water 23.4 2.26 21.47 24.6 12 50% dimethomorph wettable powder 126.6 2.64 12.81 61.5 Expected control efficiency after mixing the — — — 71.0 two components 32% benziothiazolinone•dimethomorph 150 2.65 4.37 86.9 suspension (benziothiazolinone:dimethomorph = 5:27) Embodiment 15% benziothiazolinone emulsion in water 146.6 2.54 5.60 82.5 20 50% dimethomorph wettable powder 3.4 2.52 30.90 2.7 Expected control efficiency after mixing the — — — 83.0 two components 88% benziothiazolinone•dimethomorph 150.0 2.51 4.36 86.2 wettable powder (benziothiazolinone:dimethomorph = 86:2) Embodiment 15% benziothiazolinone emulsion in water 75.0 2.72 14.29 58.3 21 50% dimethomorph wettable powder 75.0 2.81 23.79 32.8 Expected control efficiency after mixing the — — — 72.0 two components benziothiazolinone•dimethomorph wettable 150.0 2.41 3.49 88.5 powder (benziothiazolinone:dimethomorph = 25:25) Embodiment 15% benziothiazolinone emulsion in water 4.8 2.36 28.58 3.9 22 50% dimethomorph wettable powder 145.2 2.32 7.54 74.2 Expected control efficiency after mixing the — — — 75.2 two components 50% benziothiazolinone•dimethomorph 150.0 2.55 4.88 84.8 wettable powder (benziothiazolinone:dimethomorph = 2:60) Embodiment 15% benziothiazolinone emulsion in water 50.0 2.82 21.07 40.7 31: 50% dimethomorph wettable powder 100.0 2.53 16.74 47.5 Expected control efficiency after mixing the — — — 68.9 two components 15% benziothiazolinone•dimethomorph 150.0 2.63 3.48 89.5 microemulsion (benziothiazolinone:dimethomorph = 5:10) Embodiment 15% benziothiazolinone emulsion in water 100.0 2.66 10.66 68.2 32 50% dimethomorph wettable powder 50.0 2.39 22.86 24.1 Expected control efficiency after mixing the — — — 75.9 two components 15% benziothiazolinone•dimethomorph 150.0 2.35 3.58 87.9 microemulsion (benziothiazolinone:dimethomorph == 10:5) Embodiment 15% benziothiazolinone emulsion in water 136.4 2.56 6.90 78.6 39 50% dimethomorph wettable powder 13.6 2.25 26.91 5.1 Expected control efficiency after mixing the — — — 79.7 two components 22% benziothiazolinone•dimethomorph 150.0 3.01 5.20 86.3 emulsion in water (benziothiazolinone:dimethomorph = 20:2) Embodiment 15% benziothiazolinone emulsion in water 13.6 2.51 27.14 14.2 40 50% dimethomorph wettable powder 136.4 2.62 10.63 67.8 Expected control efficiency after mixing the — — — 72.4 two components 22% benziothiazolinone•dimethomorph 150.0 2.51 3.83 87.9 emulsion in water (benziothiazolinone:dimethomorph = 2:20) Embodiment 15% benziothiazolinone emulsion in water 125.0 2.52 8.35 73.7 47 50% dimethomorph wettable powder 25.0 2.35 26.77 9.6 Expected control efficiency after mixing the — — — 76.2 two components 30% benziothiazolinone•dimethomorph oil 150.0 2.69 4.91 85.5 suspension (benziothiazolinone:dimethomorph = 25:5) Embodiment 15% benziothiazolinone emulsion in water 7.1 2.55 29.95 6.8 48 50% dimethomorph wettable powder 142.9 2.21 8.02 71.2 Expected control efficiency after mixing the — — — 73.2 two components 42% benziothiazolinone•dimethomorph oil 150.0 2.36 4.10 86.2 suspension (benziothiazolinone:dimethomorph = 2:40) Water — — 2.58 32.51 — control (CK)

Test results (Table 6) show that, the compound benziothiazolinone and dimethomorph has significantly improved control efficiency on litchi blight, indicating that the compound of the two has a significant synergistic effect on litchi blight.

(3) Field Efficacy Verification Test of Compound Benziothiazolinone and Iprodione on Pepper Cinerea

TABLE 7 Prevention and treatment effect of compound benziothiazolinone and iprodione on pepper cinerea 11 days after second application of Disease index chemicals Application before Control Serial amount application of Disease efficiency number Chemicals for treatment (a.i.g/ha) reagents index (%) Embodiment 5 15% benziothiazolinone emulsion in water 174.2 3.32 9.60 75.8 50% iprodione suspension 5.8 3.11 35.98 3.2 Expected control efficiency after mixing the — — — 76.6 two components 62% benziothiazolinone•iprodione water 180.0 3.52 6.77 83.9 dispersible granule (benziothiazolinone:iprodione = 60:2) Embodiment 6 15% benziothiazolinone emulsion in water 4.8 3.32 35.91 9.5 50% iprodione suspension 175.2 3.89 14.09 69.7 Expected control efficiency after mixing the — — — 72.6 two components 75% benziothiazolinone•iprodione water 180.0 3.51 7.26 82.7 dispersible granule (benziothiazolinone:iprodione = 2:73) Embodiment 15% benziothiazolinone emulsion in water 163.6 2.85 10.01 70.6 13 50% iprodione suspension 16.4 2.98 32.30 9.3 Expected control efficiency after mixing the — — — 73.3 two components 55% benziothiazolinone•iprodione 180.0 3.11 5.91 84.1 suspension (benziothiazolinone:iprodione = 50:5) Embodiment 15% benziothiazolinone emulsion in water 8.6 3.21 32.30 15.8 14 50% iprodione suspension 171.4 3.14 13.81 63.2 Expected control efficiency after mixing the — — — 69.0 two components 42% benziothiazolinone•iprodione 180.0 3.15 6.55 82.6 suspension (benziothiazolinone:iprodione = 2:40) Embodiment 15% benziothiazolinone emulsion in water 175.8 2.84 8.11 76.1 23 50% iprodione suspension 4.2 2.92 33.88 2.9 Expected control efficiency after mixing the — — — 76.8 two components 85% benziothiazolinone•iprodione wettable 180.0 2.82 5.59 83.4 powder (benziothiazolinone:iprodione = 83:2) Embodiment 15% benziothiazolinone emulsion in water 90.0 3.76 23.68 47.3 24 50% iprodione suspension 90.0 3.24 26.60 31.3 Expected control efficiency after mixing the — — — 63.8 two components 50% benziothiazolinone•iprodione wettable 180.0 3.35 4.88 87.8 powder (benziothiazolinone:iprodione = 25:25) Embodiment 15% benziothiazolinone emulsion in water 4.2 3.31 35.68 9.8 25 50% iprodione suspension 175.8 3.22 13.70 64.4 Expected control efficiency after mixing the — — — 67.9 two components 85% benziothiazolinone•iprodione wettable 180.0 3.45 7.38 82.1 powder (benziothiazolinone:iprodione = 2:83) Embodiment 15% benziothiazolinone emulsion in water 60.0 3.72 30.90 30.5 33 50% iprodione suspension 120.0 3.13 18.25 51.2 Expected control efficiency after mixing the — — — 66.1 two components 18% benziothiazolinone•iprodione 180.0 3.42 4.82 88.2 microemulsion (benziothiazolinone:iprodione = 6:12) Embodiment 15% benziothiazolinone emulsion in water 171.4 3.26 10.05 74.2 34 50% iprodione suspension 8.6 3.11 35.20 5.3 Expected control efficiency after mixing the — — — 75.6 two components 21% benziothiazolinone•iprodione 180.0 3.32 6.55 83.5 microemulsion (benziothiazolinone:iprodione = 20:1) Embodiment 15% benziothiazolinone emulsion in water 150.0 3.56 15.91 62.6 41 50% iprodione suspension 30.0 3.25 31.19 19.7 Expected control efficiency after mixing the — — — 70.0 two components 30% benziothiazolinone•iprodione 180.0 3.41 5.34 86.9 emulsion in water (benziothiazolinone:iprodione = 25:5) Embodiment 15% benziothiazolinone emulsion in water 8.6 3.51 35.44 15.5 42 50% iprodione suspension 171.4 3.12 14.43 61.3 Expected control efficiency after mixing the — — — 67.3 two components 42% benziothiazolinone•iprodione 180.0 3.11 6.28 83.1 emulsion in water (benziothiazolinone:iprodione = 2:40) Embodiment 15% benziothiazolinone emulsion in water 30.0 3.22 30.48 20.8 49 50% iprodione suspension 150.0 2.96 13.69 61.3 Expected control efficiency after mixing the — — — 69.3 two components 18% benziothiazolinone•iprodione oil 180.0 2.90 3.99 88.5 suspension (benziothiazolinone:iprodione = 3:15) Embodiment 15% benziothiazolinone emulsion in water 163.6 2.86 10.36 69.7 50 50% iprodione suspension 16.4 2.91 31.44 9.6 Expected control efficiency after mixing the — — — 72.6 two components 22% benziothiazolinone•iprodione oil 180.0 3.19 6.33 83.4 suspension (benziothiazolinone:iprodione = 20:2) Water — — 3.21 38.36 — control (CK)

Test results (Table 7) show that, the compound benziothiazolinone and iprodione has significantly improved control efficiency on pepper cinerea, indicating that the compound of the two has a significant synergistic effect on pepper cinerea.

(4) Field Efficacy Verification Test of Compound Benziothiazolinone and Epoxiconazol Mixture on Sigatoka

TABLE 8 Prevention and treatment effect of compound benziothiazolinone and epoxiconazol on sigatoka 11 days after second application Disease of chemicals Application index before Control Serial amount application Disease efficiency number Chemicals for treatment (a.i.g/ha) of reagents index (%) Embodiment 7 15% benziothiazolinone emulsion in water 96.8 3.11 9.90 76.2 50% epoxiconazol suspension 3.2 3.23 41.45 4.1 Expected control efficiency after mixing the — — — 77.2 two components 62% benziothiazolinone•epoxiconazol water 100.0 3.52 7.49 84.1 dispersible granule (benziothiazolinone:epoxiconazol ratio = 60:2) Embodiment 8 15% benziothiazolinone emulsion in water 3.2 3.81 47.26 7.3 50% epoxiconazol suspension 96.8 3.92 17.41 66.8 Expected control efficiency after mixing the — — — 69.2 two components 62% benziothiazolinone•epoxiconazol water 100.0 3.28 7.55 82.8 dispersible granule (benziothiazolinone:epoxiconazol ratio = 2:60) Embodiment 15% benziothiazolinone emulsion in water 90.9 3.69 13.77 72.1 15 50% epoxiconazol suspension 9.1 3.72 46.44 6.7 Expected control efficiency after mixing the — — — 74.0 two components 55% benziothiazolinone•epoxiconazol 100.0 3.71 7.10 85.7 suspension (benziothiazolinone:epoxiconazol ratio = 50:5) Embodiment 15% benziothiazolinone emulsion in water 9.1 3.55 38.52 18.9 16 50% epoxiconazol suspension 90.9 3.88 20.40 60.7 Expected control efficiency after mixing the — — — 68.1 two components 55% benziothiazolinone•epoxiconazol 100.0 3.83 7.28 85.8 suspension (benziothiazolinone:epoxiconazol ratio = 5:50) Embodiment 15% benziothiazolinone emulsion in water 2.3 3.56 44.82 5.9 26 50% epoxiconazol suspension 97.7 3.34 14.39 67.8 Expected control efficiency after mixing the — — — 69.7 two components 88% 100.0 3.63 8.21 83.1 benziothiazolinone•epoxiconazolwettable powder (benziothiazolinone:epoxiconazol ratio = 2:86) Embodiment 15% benziothiazolinone emulsion in water 97.3 3.55 11.16 76.5 27 50% epoxiconazol suspension 2.3 3.87 49.76 3.9 Expected control efficiency after mixing the — — — 77.4 two components 86% benziothiazolinone•epoxiconazol 100.0 3.93 9.04 82.8 wettable powder (benziothiazolinone:epoxiconazol ratio = 84:2) Embodiment 15% benziothiazolinone emulsion in water 50.0 3.59 25.22 47.5 28 50% epoxiconazol suspension 50.0 3.55 30.97 34.8 Expected control efficiency after mixing the — — — 65.8 two components 50% benziothiazolinone•epoxiconazol 100.0 3.42 6.96 84.8 wettable powder (benziothiazolinone:epoxiconazol ratio = 25:25) Embodiment 15% benziothiazolinone emulsion in water 16.7 3.83 37.00 27.8 35 50% epoxiconazol suspension 83.3 3.89 24.72 52.5 Expected control efficiency after mixing the — — — 65.7 two components 12% benziothiazolinone•epoxiconazol 100.0 3.65 6.40 86.9 microemulsion (benziothiazolinone:epoxiconazol ratio = 2:10) Embodiment 15% benziothiazolinone emulsion in water 66.7 3.87 25.73 50.3 36 50% epoxiconazol suspension 33.3 3.93 41.28 21.5 Expected control efficiency after mixing the — — — 61.0 two components 15% benziothiazolinone•epoxiconazol 100.0 365 800.92 83.6 microemulsion (benziothiazolinone:epoxiconazol ratio = 10:5) Embodiment 15% benziothiazolinone emulsion in water 95.2 3.68 12.41 74.8 43 50% epoxiconazol suspension 4.8 3.89 49.34 5.2 Expected control efficiency after mixing the — — — 76.1 two components 21% benziothiazolinone•epoxiconazol 100.0 2.75 5.78 84.3 emulsion in water (benziothiazolinone:epoxiconazol ratio = 20:1) Embodiment 15% benziothiazolinone emulsion in water 4.8 3.76 45.38 9.8 44 50% epoxiconazol suspension 95.2 3.55 15.86 66.6 Expected control efficiency after mixing the — — — 69.9 two components 42% benziothiazolinone•epoxiconazol 100.0 3.31 6.60 85.1 emulsion in water (benziothiazolinone:epoxiconazol ratio = 2:40) Embodiment 15% benziothiazolinone emulsion in water 83.3 3.69 18.51 62.5 51 50% epoxiconazol suspension 16.7 3.82 43.29 15.3 Expected control efficiency after mixing the — — — 68.2 two components 30% benziothiazolinone•epoxiconazol oil 100.0 3.79 7.51 85.2 suspension (benziothiazolinone:epoxiconazol ratio = 25:5) Embodiment 15% benziothiazolinone emulsion in water 33.3 3.55 31.78 33.1 52 50% epoxiconazol suspension 66.7 3.65 29.20 40.2 Expected control efficiency after mixing the — — — 60.0 two components 45% benziothiazolinone•epoxiconazol oil 100.0 3.49 6.44 86.2 suspension (benziothiazolinone:epoxiconazol ratio = 15:30) Water — — 3.58 47.9 — control (CK)

Test results (Table 8) show that, the compound benziothiazolinone and epoxiconazol has significantly improved control efficiency on sigatoka, indicating that the compound of the two has a significant synergistic effect on sigatoka. 

What is claimed is:
 1. A synergistic fungicide composition, comprising two active components A and B, wherein the active component A is benziothiazolinone, the active component B is one selected from the group consisting of dithianon, dimethomorph, iprodione and epoxiconazol, and the weight ratio of the two components is 1:50 to 50:1.
 2. The composition according to claim 1, wherein the composition is composed of 6 wt % to 92 wt % of the active components and 94 wt % to 8 wt % of fungicide adjuvants.
 3. The composition according to claim 1, wherein the weight ratio of the active component benziothiazolinone and the active component dithianon is 1:30 to 30:1.
 4. The composition according to claim 1, wherein the weight ratio of the active component benziothiazolinone and the active component dimethomorph is 1:30 to 30:1.
 5. The composition according to claim 1, wherein the weight ratio of the active component benziothiazolinone and the active component iprodione is 1:30 to 30:1.
 6. The composition according to claim 1, wherein the weight ratio of the active component benziothiazolinone and the active component epoxiconazol is 1:30 to 30:1.
 7. The composition according to claim 1, wherein the composition is formulated into any formulation allowable in agriculture.
 8. The composition according to claim 5, wherein the composition is formulated into wettable powder, a suspension, an oil suspension, a water dispersible granule, an emulsion in water and a microemulsion. 